Which substance might interact negatively with isosorbide dinitrate?

Isosorbide dinitrate is a medication primarily used for treating angina pectoris and heart failure by dilating blood vessels to improve blood flow. It works as a nitrate agent, leading to vasodilation and reducing the heart's workload.

The interaction with alcohol, such as a glass of wine, is significant because combining nitrates with alcohol can lead to enhanced vasodilatory effects. This can result in excessive drops in blood pressure, dizziness, fainting, or other cardiovascular complications. Alcohol can potentiate the hypotensive effects of nitrates, making it a risky combination.

Other substances listed, such as carvedilol, simvastatin, and aspirin, may have interactions with certain medications but do not produce the same critical negative interaction with isosorbide dinitrate as alcohol does. Therefore, it is essential to be cautious with alcohol use when treating patients on isosorbide dinitrate to avoid potential complications related to blood pressure management and overall safety.