Which route is used for sublingual nitroglycerin administration?

Sublingual nitroglycerin administration involves placing the medication under the tongue, where it rapidly dissolves and is absorbed into the bloodstream through the mucous membranes. This route is effective because it allows for quick absorption, leading to a fast onset of action, which is particularly important in treating acute angina episodes. The sublingual route circumvents the gastrointestinal tract and the first-pass metabolic effect, thereby enhancing the bioavailability of the nitroglycerin compared to other routes.

In contrast to other options, the intravenous route involves injecting the drug directly into the bloodstream, which is not how sublingual nitroglycerin is administered. The oral route suggests swallowing the medication, which would delay its effects due to digestion and first-pass metabolism. The transdermal route involves absorption through the skin, typically used for long-term management, but not for the immediate relief provided by sublingual administration. This explains why sublingual is the correct route for nitroglycerin, maximizing its therapeutic benefits when rapid action is needed.