Which of the following needs to be monitored when combining losartan with NSAIDs?

When combining losartan, an antihypertensive medication, with NSAIDs (non-steroidal anti-inflammatory drugs), monitoring for renal dysfunction is critical due to the potential risk of adverse effects on kidney function. Both losartan and NSAIDs can affect renal blood flow and function in different ways.

Losartan works by blocking angiotensin II receptors, which helps to lower blood pressure and reduce fluid retention. On the other hand, NSAIDs can reduce renal perfusion, particularly in patients who are already compromised or have certain risk factors, such as dehydration, heart failure, or pre-existing kidney issues. The interaction between these drugs can lead to acute kidney injury or worsen existing renal dysfunction.

Therefore, careful monitoring of kidney function parameters, such as serum creatinine and blood urea nitrogen (BUN), is essential when these medications are used together to prevent potentially serious complications. This focus on renal function allows for timely interventions if signs of impairment are detected, safeguarding the patient's overall health.