Which calcium channel blockers are classified as dihydropyridines and are more vascularly selective?

Dihydropyridines are a class of calcium channel blockers that are primarily used for their effects on the vasculature, leading to vasodilation. The main characteristic of dihydropyridines is their selectivity for vascular smooth muscle over cardiac tissue. This property makes them particularly effective in treating conditions such as hypertension and angina.

Amlodipine and felodipine are well-known examples of dihydropyridine calcium channel blockers. They work by blocking calcium channels in vascular smooth muscle, resulting in coronary and peripheral vasodilation, which decreases blood pressure and workload on the heart. Their strong affinity for vascular calcium channels, compared to those in the heart, underscores their role in managing hypertension without significantly affecting cardiac contractility or conduction.

In contrast, verapamil and diltiazem, which are not dihydropyridines, have more pronounced effects on the heart as they not only affect vascular smooth muscle but also influence cardiac muscle and conduction tissues. This can lead to a decrease in heart rate and contractility, making them more suitable for certain cardiac conditions but less selective for vascular use.

Choosing amlodipine and felodipine as the correct answer highlights the focus on drugs that