Which antihypertensive medication is contraindicated during pregnancy?

Angiotensin II receptor blockers (ARBs) are contraindicated during pregnancy primarily due to their potential to cause harm to the developing fetus. Use of ARBs during pregnancy is associated with serious risks, particularly during the second and third trimesters, including fetal renal dysfunction, oligohydramnios (low amniotic fluid), and various developmental abnormalities. The FDA categorizes ARBs as Category D during pregnancy, indicating that there is evidence of risk to the fetus based on studies or experience in humans.

In contrast, doxazosin, beta blockers, and calcium channel blockers are generally considered safer options for managing hypertension during pregnancy, although certain precautions and monitoring may be necessary. Thus, ARBs stand out as the antihypertensive class that is specifically discouraged in pregnant patients due to the significant risks they pose.