What is a therapeutic effect of angiotensin-converting enzyme (ACE) inhibitors?

The therapeutic effect of angiotensin-converting enzyme (ACE) inhibitors is primarily to slow the development of heart failure (HF). ACE inhibitors work by blocking the conversion of angiotensin I to angiotensin II, which is a potent vasoconstrictor that can increase blood pressure and contribute to heart failure progression. By inhibiting this conversion, ACE inhibitors help to relax blood vessels, reduce blood pressure, and decrease the workload on the heart. This reduction in workload leads to improved heart function and can significantly delay or slow the progression of heart failure.

In addition to these mechanisms, ACE inhibitors may promote better outcomes by enhancing fluid balance and reducing the strain on the heart muscle, further contributing to their beneficial role in managing heart failure. Their use is well-established in preventing the worsening of the condition and improving overall cardiac function.