What adverse reaction might a stable client taking valsartan/sacubitril experience if they report trouble talking and a swollen tongue?

The correct answer is angioedema, which is a serious and potentially life-threatening adverse reaction that can occur with the use of valsartan/sacubitril. Angioedema is characterized by localized swelling of the skin, often around the eyes, lips, and tongue, and can lead to difficulties in speaking or swallowing if the swelling is significant. In this scenario, the client reporting trouble talking and a swollen tongue is indicative of this condition, which requires prompt medical attention.

Angioedema can arise due to an increase in bradykinin levels associated with angiotensin receptor-neprilysin inhibitors like valsartan/sacubitril. This condition highlights the importance of monitoring patients closely for any signs of swelling in the face, tongue, or throat after starting therapy with this medication, especially since it may not present symptoms immediately after initiation.

The other reactions listed, such as hives, dry mouth, and nausea, do not correlate with the specific symptoms of trouble talking and a swollen tongue. While hives can indicate an allergic reaction, they typically present with raised welts rather than significant swelling of the tongue. Dry mouth and nausea are also common side effects related to various medications but do not reflect the acute and urgent nature