Isosorbide dinitrate is indicated for which condition in addition to angina?

Isosorbide dinitrate is primarily indicated for the management of angina, but it also has important applications in heart failure. The medication acts as a vasodilator, which helps to reduce the workload on the heart by decreasing preload and afterload. In heart failure, the heart struggles to pump effectively, and reducing the pressure in the veins (venous return) can alleviate symptoms and improve overall heart function.

By dilating blood vessels, isosorbide dinitrate can enhance blood flow and reduce the strain on the heart, making it a valuable treatment option for patients experiencing heart failure symptoms. This is particularly relevant in cases of chronic heart failure, where fluid overload and elevated pressures in the heart can lead to significant complications.

In contrast, while the other listed conditions—hypertension, heart attack, and atrial fibrillation—have their own unique treatment protocols, isosorbide dinitrate is specifically beneficial in the context of heart failure due to its mechanism of reducing heart strain and improving hemodynamics.