Which angiotensin-converting enzyme (ACE) inhibitor is not metabolized through the liver?

Lisinopril is distinct among ACE inhibitors because it is not metabolized through the liver; instead, it is excreted unchanged primarily by the kidneys. This characteristic makes it particularly suitable for patients with liver impairment, as it does not rely on hepatic metabolism for its action or clearance.

In contrast, the other ACE inhibitors listed—the ones metabolized by the liver—undergo extensive hepatic processing, which can be affected in patients with liver dysfunction. Therefore, knowing that lisinopril's primary route of excretion is renal rather than hepatic highlights its unique pharmacokinetic profile.