In which condition is amlodipine contraindicated?

Amlodipine is a calcium channel blocker primarily used to treat hypertension and certain types of angina. In the case of aortic stenosis, the use of amlodipine can lead to significant cardiovascular complications. This is due to the fact that aortic stenosis causes a narrowing of the outflow tract in the heart, which means that the heart has to work harder to pump blood through the aortic valve. Amlodipine can cause peripheral vasodilation, which may lead to a decrease in systemic vascular resistance and consequently a drop in blood pressure. This reduction in blood pressure can be particularly dangerous in patients with aortic stenosis as it can decrease coronary perfusion and precipitate heart failure or lead to syncope due to inadequate blood flow.

In contrast, the other conditions listed—such as asthma, diabetes, and hyperlipidemia—do not have a direct contraindication with amlodipine. While caution may be warranted in patients with these conditions, amlodipine is generally considered safe and effective in managing hypertension in these populations.